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KIF5A mutations, age may drive neurodegeneration in ALS: Study

Mutations in the KIF5A gene, associated with some cases of amyotrophic lateral sclerosis (ALS), may lead to impairments in motor unit recovery that are exacerbated with age, according to a recent study. Motor units — nerve cells involved in movement and the muscle fibers they interact with — showed poor…

Age and Sex Strongly Influence ALS Type and Symptoms, Study Finds

The onset and early progression of motor and cognitive symptoms, specific by disease type to each amyotrophic lateral sclerosis (ALS) patient, are determined by age and sex, and to some extent by mutations in ALS genes, a large data study has found. The study, “ALS phenotype is influenced…

Higher Risk of Pressure Sores in ALS Patients; Women, Young More Vulnerable, Study Finds

Patients with amyotrophic lateral sclerosis (ALS) are at increased risk for having pressure sores (PrS), according to a recent study. This risk is especially high for women and young patients, the findings showed. The study “Risk of developing PrS in amyotrophic lateral sclerosis patients – a nationwide cohort…

Increased Risk of ALS Appears Linked to Physical Trauma at Early Age

Physical trauma at earlier ages appears associated with an increased risk of amyotrophic lateral sclerosis (ALS), according to a study titled “Physical Trauma and Amyotrophic Lateral Sclerosis: A Population-Based Study Using Danish National Registries” published in the American Journal of Epidemiology. ALS, also known as Lou Gehrig’s disease and Charcot…