familial ALS

Amyotrophic lateral sclerosis, also know as ALS or Lou Gehrig’s disease, is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. There are two different types of ALS: sporadic and familial. To help you understand more about this disease, we’ve put together a list with…

The amount of RNA molecules present in the blood and central nervous system of amyotrophic lateral sclerosis (ALS) patients seems to play a role in the onset and development of the disease, a study published in the journal Scientific Reports showed. A better understanding of the involvement of RNA molecules…

Neurodegeneration in a subset of amyotrophic lateral sclerosis (ALS) patients is a consequence of abnormal DNA damage responses, a finding that provides new possibilities for therapeutic interventions. About 5 percent of familial amyotrophic lateral sclerosis (fALS), and up to 1 percent of sporadic ALS (sALS), have been linked to mutations in…

Gene editing may be a viable tool to slow disease-causing processes in amyotrophic lateral sclerosis (ALS) caused by mutations in the SOD1 gene, a mouse study indicates. Published in the journal Science Advances, the study demonstrated that the method delayed disease…

Ludwig Cancer Research scientist Don Cleveland has received a $3 million Breakthrough Prize for increasing science’s understanding of how an inherited form of amyotrophic lateral sclerosis develops. His work focused on glia, cells that support the body’s production of a protein called myelin, which protects nerve cells. Deterioration of myelin…

Rare genetic mutations that affect functionally related proteins act in a synergistic manner to determine the course of ALS, a new genetic screening study shows. It also points to several new mutations that might lead to this disease. “We provide evidence for a number of entirely novel genetic variants of…

Severe DNA damage and other disease-associated hallmarks are absent in a mouse model of familial amyothrophic lateral sclerosis (fALS), a new study shows. The study, “DNA strand breaks and TDP-43 mislocation are absent in the murine hSOD1G93A model of amyotrophic lateral sclerosis in vivo and in vitro,” appeared in the journal…

Wave Life Sciences is developing two ALS and frontotemporal dementia therapies that target a gene mutation common in both. The therapies target mutations of the C9orf72 gene, Wave said in a business update. “I am excited to announce our next development program targeting C9orf72 mutations in ALS and FTD,” Dr.

Amyotrophic lateral sclerosis, also know as ALS or Lou Gehrig’s disease, is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. There are two different types of ALS: sporadic and familial. To help you understand more about this disease, we’ve put together a list with…

Around 90 percent of amyotrophic lateral sclerosis (ALS) cases are considered sporadic with no family history of the disease, but the remaining 10 percent are cases where ALS runs in the family. Often patients with familial ALS (FALS) also suffer from frontotemporal dementia, which is due to mutated genes that get passed down through the family.